原创力文档screening for compounds with aromatase inhibiting activities from atractylodes macrocephala koidz筛查化合物与芳香化酶抑制活动从白术macrocephala koidz.pdfVIP
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screening for compounds with aromatase inhibiting activities from atractylodes macrocephala koidz筛查化合物与芳香化酶抑制活动从白术macrocephala koidz
Molecules 2011, 16, 3146-3151; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Communication
Screening for Compounds with Aromatase Inhibiting Activities
from Atractylodes macrocephala Koidz
Hai Jiang 1, Jing Shi 2,* and Yuanyuan Li 2
1 Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, No.79
Qingchun Rd., Hangzhou 310003, China; E-Mail: jhai123@
2 Department of Pharmacy, Zhejiang Medical College, No.481 Binwen Rd., Hangzhou 310053,
China
* Author to whom correspondence should be addressed; E-Mail: shij136@;
Tel.: +86-571 Fax: +86-571
Received: 31 March 2011; in revised form: 11 April 2011 / Accepted: 12 April 2011 /
Published: 14 April 2011
Abstract: Ten compounds were isolated from the dichloromethane extract of Atractylodes
macrocephala and their aromatase inhibiting activities were tested using an in vitro
fluorescent-based aromatase assay. The results indicated that atractylenolide I (1),
atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%,
90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude
from our results that atractylenolide and its derivates may serve as potential aromatase
inhibitors (AIs) and thus merit continued study in the future.
Keywords: aromatase; Atractylodes macrocephala ; atractylenolide
1. Introduction
Breast cancer is one of
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