secondary metabolites from the roots of beilschmiedia tsangii and their anti-inflammatory activities根的次生代谢物beilschmiedia tsangii及其抗炎活动.pdfVIP

Int. J. Mol. Sci. 2012, 13, 16430-16443; doi:10.3390/ijms131216430 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities Yun-Ting Huang 1,†, Hsun-Shuo Chang 1,†, Guei-Jane Wang 2,3, Chu-Hung Lin 4 and Ih-Sheng Chen 1,4,* 1 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; E-Mails: leave.alone@ (Y.-T.H.); hschang@.tw (H.-S.C.) 2 L5 Research Center, China Medical University Hospital, Taichung 40447, Taiwan; E-Mail: jennyw355@ 3 Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan 4 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; E-Mail: .tw † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: m635013@.tw; Tel.: +886-7-312-1101 (ext. 2191); Fax: +886-7-321-0683. Received: 24 September 2012; in revised form: 19 November 2012 / Accepted: 21 November 2012 / Published: 3 December 2012 Abstract: Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll- 8(13)-ene (7), together with four known co