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Review Secretome: clues into pathogen infection and clinical applications † Shoba Ranganathan* and Gagan Garg* Addresses: *Department of Chemistry and Biomolecular Sciences and ARC Centre of Excellence in Bioinformatics, Macquarie University, Sydney NSW 2109, Australia. †Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597 Singapore. Correspondence: Shoba Ranganathan. Email: shoba.ranganathan@.au A brief overview of the currently available methods for Abstract generating and analyzing pathogen secretome data is pre­ The secretome encompasses the complete set of gene products secreted by a cell. Recent studies on secretome analysis reveal sented, followed by a critical analysis of their contribution that secretory proteins play an important role in pathogen to our understanding of pathogen infection and host infection and host-pathogen interactions. Excretory/secretory responses, especially in comparison to other genome proteins of pathogens change the host cell environment by analysis approaches. Some early successes in the applica­ suppressing the immune system, to aid the proliferation of tions of secretome data in the areas of therapeutic target infection. Identifying secretory proteins involved in pathogen identification, diagnostic tools and pathogen control are infection will lead to the discovery of potential drug targets and biomarkers for diagnostic applications. also presented. Introd