selective coupling between theta phase and neocortical fast gamma oscillations during rem-sleep in mice选择性θ相之间的耦合和皮层快速伽马振荡在rem睡眠期间老鼠.pdfVIP

Selective Coupling between Theta Phase and Neocortical Fast Gamma Oscillations during REM-Sleep in Mice ¨ 1 2 3 1 4. Claudia Scheffzuk , Valeriy I. Kukushka , Alexei L. Vyssotski , Andreas Draguhn , Adriano B. L. Tort , ˇ 1*. Jurij Brankack 1 Institute for Physiology and Pathophysiology, University Heidelberg, Heidelberg, Germany, 2 Quantum Chromoplasma Laboratory, Dniepropetrovsk National University, ¨ ¨ Dniepropetrovsk, Ukraina, 3 Institute of Neuroinformatics, University of Zurich/ETH, Zurich, Switzerland, 4 Brain Institute, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil Abstract Background: The mammalian brain expresses a wide range of state-dependent network oscillations which vary in frequency and spatial extension. Such rhythms can entrain multiple neurons into coherent patterns of activity, consistent with a role in behaviour, cognition and memory formation. Recent evidence suggests that locally generated fast network oscillations can be systematically aligned to long-range slow oscillations. It is likely that such cross-frequency coupling supports specific tasks including behavioural choice and working memory. Principal Findings: We analyzed temporal coupling between high-frequency oscillations and EEG theta activity (4–12 Hz) in recordings from mouse parietal neocortex. Theta was exclusively present during active wakefulness and REM-sleep. Fast oscillations occurred in two separate frequency bands: gamma (40–100 Hz) and fast gamma (120–160 Hz). Theta, gamma