原创力文档search for hydrophilic marine fungal metabolites a rational approach for their production and extraction in a bioactivity screening context寻找亲水海洋真菌代谢物的理性方法生产和提取生物活性筛选上下文.pdfVIP
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search for hydrophilic marine fungal metabolites a rational approach for their production and extraction in a bioactivity screening context寻找亲水海洋真菌代谢物的理性方法生产和提取生物活性筛选上下文
Mar. Drugs 2011, 9, 82-97; doi:10.3390/md9010082
OPEN ACCESS
Marine Drugs
ISSN 1660-3397
/journal/marinedrugs
Article
Search for Hydrophilic Marine Fungal Metabolites: A Rational
Approach for Their Production and Extraction in a Bioactivity
Screening Context
Carine Le Ker, Karina-Ethel Petit, Jean-François Biard and Joël Fleurence *
University of Nantes, Faculty of Pharmacy, MMS–EA 2160, F-44000 Nantes, France;
E-Mails: carine.le-ker@etu.univ-nantes.fr (C.L.K.); karina.petit@univ-nantes.fr (K.-E.P.);
jean -francois.biard@univ-nantes.fr (J.-F.B.)
* Author to whom correspondence should be addressed; E-Mail: joel.fl eurence@univ-nantes.fr;
Tel.: +33 2 51 12 56 60; Fax: +33 2 51 12 56 68.
Received: 18 December 2010; in revised form: 30 December 2010 / Accepted: 5 January 2011 /
Published: 10 January 2011
Abstract: In the search for bioactive natural products, our lab screens hydrophobic extracts
from marine fungal strains. While hydrophilic active substances were recently identified
from marine macro-organisms, there was a lack of reported metabolites in the marine fungi
area. As such, we decided to develop a general procedure for screening of hydrophobic
metabolites. The aim of this study was to compare different processes of fermentation and
extraction, using six representative marine fungal strains, in order to define the optimized
method for production. The parameters studied were (a) which polar solvent to select,
(b) which fermentation method to choose between solid and liquid cu
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