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searching genomes for ribozymes and riboswitches基因组寻找核糖酶和riboswitches
Review
Searching genomes for ribozymes and riboswitches
Christian Hammann* and Eric Westhof†
Addresses: *Research Group Molecular Interactions, Department of Genetics, FB 18 Naturwissenschaften, Universität Kassel, D-34132
Kassel, Germany. †Architecture et Réactivité de l’ARN, Université Louis Pasteur de Strasbourg, Institut de Biologie Moléculaire et Cellulaire,
CNRS, rue René Descartes, F-67084 Strasbourg Cedex, France.
Correspondence: Eric Westhof. Email: E.Westhof@ibmc.u-strasbg.fr
Published: 30 April 2007
Genome Biology 2007, 8:210 (doi:10.1186/gb-2007-8-4-210)
The electronic version of this article is the complete one and can be
found online at /2007/8/4/210
© 2007 BioMed Central Ltd
Abstract
New regulatory RNAs with complex structures have recently been discovered, among them the
first catalytic riboswitch, a gene-regulatory RNA sequence with catalytic activity. Here we discuss
some of the experimental approaches and theoretical difficulties attached to the identification of
new ribozymes in genomes.
Catalysis by RNA was discovered a quarter of a century ago. dramatically from each other in their architecture and
The discoveries that certain introns were capable of self- exhibit significant variation in the pH profiles of their
splicing [1] and that the RNA moiety of bacterial ribo- catalytic activity and in the metal ions required for catalysis
nuclease P (RNase P) on its own could process precursor [11]. It seems likely that this reaction mechanism is best
tRNAs [2] were the first indications that catalytic remnants suited to a simple and single RNA cleavage, as in the proces-
of a postulated RNA world had persisted until the present sing of multimeric replication in
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