searching for lower female genital tract soluble and cellular biomarkers defining levels and predictors in a cohort of healthy caucasian women寻找更低的女性生殖道可溶性和细胞生物标记定义水平和预测在一群健康的白人女性.pdfVIP

Searching for Lower Female Genital Tract Soluble and Cellular Biomarkers: Defining Levels and Predictors in a Cohort of Healthy Caucasian Women 1 2 3 1 4 5 Jordan K. Kyongo , Vicky Jespers , Odin Goovaerts , Johan Michiels , Joris Menten , Raina N. Fichorova , 6 1,7 ¨ 1 Tania Crucitti , Guido Vanham , Kevin K. Arien * 1Virology Unit, Division of Microbiology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, 2 ITM HIV/AIDS Centre, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium, 3 Immunology Unit, Division of Microbiology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, 4 Clinical Trials Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, 5 Laboratory of Genital Tract Biology, Department of Obstetrics, Gynaecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 6 HIV/STI Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Institute of Tropical Medicine, Antwerp, Belgium, 7 Faculty of Pharmaceutical, Veterinary and Biomedical Sciences, University of Antwerp, Antwerp, Belgium and Faculty of Medicine and Pharmacology, University of Brussels, Brussels, Belgium Abstract Background: High concentrations of pro-inflammatory cytokines have been previously observed in the genital fluids of women enrolled in microbicide trials and may explain observed increased HIV transmission in some of these trials. Although the longitudinal nature of these studies allows within-subject comparisons of post-product levels to ba