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season of birth and risk for adult onset glioma神经胶质瘤出生季节和成人发病的风险
Int. J. Environ. Res. Public Health 2010, 7, 1913-1936; doi:10.3390/ijerph7051913
OPEN ACCESS
International Journal of
Environmental Research and
Public Health
ISSN 1660-4601
/journal/ijerph
Review
Season of Birth and Risk for Adult Onset Glioma
Jimmy T. Efird
Center for Health of Vulnerable Populations, Office of the Dean, School of Nursing, University of
North Carolina, 237A McIver Building, Administrative Drive, Greensboro, NC 27402-6170, USA;
E-Mail: jimmy.efird@stan ; Tel.: +1-650-248-8282
Received: 6 January 2010; in revised form: 4 February 2010 / Accepted: 11 February 2010 /
Published: 28 April 2010
Abstract: Adult onset glioma is a rare cancer which occurs more frequently in Caucasians
than African Americans, and in men than women. The etiology of this disease is largely
unknown. Exposure to ionizing radiation is the only well established environmental risk
factor, and this factor explains only a small percentage of cases. Several recent studies have
reported an association between season of birth and glioma risk. This paper reviews the
plausibility of evidence focusing on the seasonal interrelation of farming, allergies, viruses,
vitamin D, diet, birth weight, and handedness. To date, a convincing explanation for the
occurrence of adult
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