rucl3·3h2o catalyzed reactions facile synthesis of bis(indolyl)methanes under mild conditionsrucl3·3 h2o灵巧的bis(indolyl)甲烷的合成催化反应在温和的条件下.pdfVIP
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rucl3·3h2o catalyzed reactions facile synthesis of bis(indolyl)methanes under mild conditionsrucl3·3 h2o灵巧的bis(indolyl)甲烷的合成催化反应在温和的条件下
Molecules 2011, 16, 3855-3868; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
RuCl ·3H O Catalyzed Reactions: Facile Synthesis of
3 2
Bis(indolyl)methanes under Mild Conditions
Hong-En Qu, Chen Xiao, Ning Wang, Kai-Hui Yu, Qiao-Sheng Hu * and Liang-Xian Liu *
Department of Chemistry and Biology, Gannan Normal University, Ganzhou, Jiangxi 341000, China;
E-Mails: quhongen-2003@163.com (H.-E.Q.); xiaocen1219@163.com (C.X.);
wangning198415@126.com (N.W.); ykh506@163.com (K.-H.Y.)
* Author to whom correspondence should be addressed; E-Mails: lxliu@ (L.-X.L.);
huqiaosheng@ (Q.-S.H.); Tel.: +86-797-839-7630; Fax: +86-797-839-3670.
Received: 23 March 2011; in revised form: 20 April 2011 / Accepted: 25 April 2011 /
Published: 9 May 2011
Abstract: RuCl ·3H O was found to be an effective catalyst for reactions of indoles,
3 2
2-methylthiophene, and 2-methylfuran with aldehydes to afford the corresponding
bis(indolyl)methanes, bis(thienyl)methanes, and bis(fur-2-yl)methanes in moderate to
excellent yields. Experimental results indicated that mono(indolyl)methanol is not the
reaction intermediate under these reaction conditions.
Keywords: bis(indolyl)methane; RuCl ·3H O; aldehyde; indole
3 2
1. Introduction
Indoles and their derivatives are known to possess various pharmacological a
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