钙摄入和心血管病死亡率.pdfVIP

ORIGINAL INVESTIGATION ONLINE FIRST | LESS IS MORE Dietary and Supplemental Calcium Intake and Cardiovascular Disease Mortality The National Institutes of Health–AARP Diet and Health Study Qian Xiao, PhD; Rachel A. Murphy, PhD; Denise K. Houston, PhD; Tamara B. Harris, MD; Wong-Ho Chow, PhD; Yikyung Park, ScD Importance: Calcium intake has been promoted be- graphic, lifestyle, and dietary variables were used to es- cause of its proposed benefit on bone health, particu- timate relative risks (RRs) and 95% CIs. larly among the older population. However, concerns have been raised about the potential adverse effect of high cal- Results: During a mean of 12 years of follow-up, 7904 cium intake on cardiovascular health. and 3874 CVD deaths in men and women, respectively, were identified. Supplements containing calcium were Objective: To investigate whether intake of dietary and used by 51% of men and 70% of women. In men, supple- supplemental calcium is associated with mortality from mental calcium intake was associated with an elevated total cardiovascular disease (CVD), heart disease, and cere- risk of CVD death (RR1000 vs 0 mg/d, 1.20; 95% CI, 1.05- brovascular diseases. 1.36), more specifically with heart disease death (RR, 1.19; 95% CI, 1.03-1.37) but not significantly with cerebro- Design and Setti