[PDF] 无机米粒子作为基因载体的研究进展.pdfVIP

20 3 Vol. 20, No. 3 2008 6 Chinese Bulletin of Life Sciences Jun., 2008 1004-0374(2008)03-0402-06 , 300071 TN3 83 Q78 2 R39 4 A Progress of inorganic nanoparticles as gene delivery vectors LI Xin-xin HOU Sen FENG Xi-zeng* (The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China) Abstract: Transfection is defined as the delivery of functional nucleic acids into living cells, maintaining the biological function of the nucleic acids. As an important technique in biochemistry and molecular biology, transfection is meaningful for its potential applications in gene therapy. Inorganic nanoparticles can be used as gene delivery vectors and have received extensive interest due to their various advantages, such as easy preparation and surface-functionalization. This paper reviewed the current researches about inorganic nanoparticles as gene delivery vectors. Their influence on the gene expression was also discussed. Key words: transfection inorganic nanoparticles gene vectors gene therapy (DNARNA ) [1] , : 1 [3] [2] 2008-04-14 2008-05-07 * E-mail: xzfeng@nankai.edu.cn 403 (1) DNARNA DNA ( pH 5) DNA