nt-probnp结合多普勒技术对舒张性心力衰竭患者的评价.docVIP

NT-proBNP结合组织多普勒技术对舒张性心力衰竭患者的评估 杨 奕1 肖 骅1 1重庆医科大学附属第一医院，重庆 400016 [摘要] 目的 探讨二尖瓣舒张早期血流峰速度／二尖瓣环舒张早期运动峰速度(early filling/early diastoliemitral annular velocity，E/Ea)结合N末端脑利钠肽前体(N-terminal pro-brain natriuretic peptide，NT-proBNP)诊断舒张性心力衰竭(diastolic heart failure，DHF)的意义。方法 将我科收治的57例DHF患者，按NYHA分级分为、、级, 另选取同期住院或体检心功能正常者18例为对照组。分别对各组行超声心动图检测。同期检测血清NT-pro BNP浓度，并对结果进行统计学处理。结果 与对照组相比，DHF组患者E/Ea、NT-proBNP显著升高且有统计学差异(P0.001)。随着心力衰竭的加重，NT-proBNP浓度和E/Ea比值逐渐升高。多元回归分析显示，lg NT-proBNP水平与左室射血分数、E/Ea独立相关(R2=0.374,P=0.000)，与E/Ea相关性最强(β=0.677)。结论 在测定NT-proBNP浓度的基础上，结合组织多普勒超声检测E/Ea值，可协助诊断DHF和评价左室功能。 [关键词] 舒张性心力衰竭；二尖瓣舒张早期血流峰速度/二尖瓣环舒张早期运动峰速度；N末端脑利钠肽前体 [中图法分类号] R541.6 [文献标识码] A Evaluation of patients with diastolic heart failure by NT-proBNP and Tissue Doppler imaging Yang Yi1 Xiao Hua1 （1Department of Cardiology of the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016,China） [Abstract] Objective To explore the significance diagnosis of diastolic heart failure by mitral value peak flow velocity in early diastole/ early diastoliemitral annular velocity(E/Ea) and N-terminal pro-brain natriuretic peptide(NT-proBNP). Method 57 cases of DHF patients were admitted to our department, which were divided into Ⅱ、Ⅲ、Ⅳ grade according to the NYHA classification, Meanwhile, another 18 patients in hospitalization or with normal heart function after medical examinations were selected as the control group. They underwent conventional and tissue Doppler imaging and serum NT-proBNP level was measured at the same time, and the results were analyzed statistically. Results Compared with the control group, E/Ea and NT-proBNP of DHF patients were significantly higher and statistically significant (P 0.001). With the aggravation of heart failure, concentration of NT-proBNP and E/Ea ratio were gradually increased.The Multiple regression analysis showed lg NT-proBNP level were independently related to