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snedds containing poorly water soluble cinnarizine; development and in vitro characterization of dispersion, digestion and solubilizationsnedds含有水溶性差桂利嗪;.pdf

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snedds containing poorly water soluble cinnarizine; development and in vitro characterization of dispersion, digestion and solubilizationsnedds含有水溶性差桂利嗪;

Pharmaceutics 2012, 4, 641-665; doi:10.3390/pharmaceutics4040641 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Article SNEDDS Containing Poorly Water Soluble Cinnarizine; Development and in Vitro Characterization of Dispersion, Digestion and Solubilization 1 1 2 3 Anne T. Larsen , Anayo Ogbonna , Ragheb Abu-Rmaileh , Bertil Abrahamsson , Jesper Østergaard 1 and Anette Müllertz 1,4,* 1 Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark; E-Mails: anne.tungelund@sund.ku.dk (A.T.L.); annyogbonna@ (A.O.); jesper.ostergaar d@sund.ku.dk (J.Ø.) 2 AstraZeneca, Pharmaceutical Development, Formulation Science, Macclesfield, United Kingdom; E-Mail: ragheb.aburmaileh@ 3 AstraZeneca, Pharmaceutical Development, Physical Science, Mölndal, Sweden; E-Mail: bertil.abrahamsson@ 4 Bioneer: FARMA, Danish Drug Development Center, Copenhagen, Denmark * Author to whom correspondence should be addressed; E-Mail: anette.mullertz@sund.ku.dk; Tel.: +45-353-364-40; Fax: +45-353-360-01. Received: 24 September 2012; in revised form: 30 November 2012 / Accepted: 3 December 2012 / Published: 14 December 2012 Abstract: Self-Nanoemulsifying Drug Delivery Systems (SNEDDSs) were developed using well-defined excipients with the objective of mimicking digested SNEDDSs without the use of enzymes and in vitro lipolysis models and thereby enabling studies of the