原创力文档solvent composition is critical for carbodiimide cross-linking of hyaluronic acid as an ophthalmic biomaterial溶剂成分是至关重要的碳化二亚胺交联透明质酸作为眼科生物材料.pdfVIP
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solvent composition is critical for carbodiimide cross-linking of hyaluronic acid as an ophthalmic biomaterial溶剂成分是至关重要的碳化二亚胺交联透明质酸作为眼科生物材料
Materials 2012, 5, 1986-2002; doi:10.3390/ma5101986
OPEN ACCESS
materials
ISSN 1996-1944
/journal/materials
Article
Solvent Composition is Critical for Carbodiimide Cross-Linking
of Hyaluronic Acid as an Ophthalmic Biomaterial
Jui-Yang Lai 1,2,3
1 Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302,
Taiwan; E-Mail: jylai@.tw; Tel.: +886-3-211-8800, ext. 3598; Fax: +886-3-211-8668
2 Biomedical Engineering Research Center, Chang Gung University, Taoyuan 33302, Taiwan
3 Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan
Received: 11 October 2012; in revised form: 16 October 2012 / Accepted: 18 October 2012 /
Published: 23 October 2012
Abstract: Hyaluronic acid (HA) is one of the most important ophthalmic biomaterials,
while also being used for tissue engineering and drug delivery. Although chemical
cross-linking is an effective way to improve the material performance, it may as a
consequence be detrimental to the living cells/tissues. Given that the cross-linking
efficiency is mediated by the solvent composition during the chemical modification, this
study aims to explore the stability and biocompatibility of carbodiimide cross-linked HA in
relation to material processing conditions by varying the acetone/water volume ratio (from
70:30 to 95:5) at a constant 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC)
concentration of 100 mM. Our
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