spatial differences in the presence of foxp3+ and granzymeb+ t cells between the intra- and extravascular compartments in renal allograft vasculopathy空间差异的存在foxp3 +和granzymeb + t细胞之间的内部,在移植肾血管病变血管外的隔间.pdfVIP

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spatial differences in the presence of foxp3+ and granzymeb+ t cells between the intra- and extravascular compartments in renal allograft vasculopathy空间差异的存在foxp3 +和granzymeb + t细胞之间的内部,在移植肾血管病变血管外的隔间.pdf

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spatialdifferencesinthepresenceoffoxp3andgranzymebtcellsbetweentheintra-andextravascularcompartmentsinrenalallograftvasculopathy空间差异的存在foxp3和granzymebt细胞之间的内部,在移植肾血管病变血管外的隔间

Spatial Differences in the Presence of FOXP3+ and GranzymeB+ T Cells between the Intra- and Extravascular Compartments in Renal Allograft Vasculopathy 1 1 1 1 1 Onno J. de Boer *, Peter Teeling , Marcel Jansen , Hanneke Ploegmakers , Chris M. van der Loos , 2 1 1 J. Alain Kummer , Sandrine Florquin , Allard C. van der Wal 1 Department of Pathology, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands, 2 Department of Pathology, St. Antonius Hospital, Nieuwegein, the Netherlands Abstract Background: Allograft vasculopathy (AV) and native atherosclerosis (NA) share the presence of a T-cell mediated inflammatory response, but differ in overall plaque morphology and growth rate. We studied the distribution and frequency of regulatory- and cytotoxic T cells in the arterial intima lesions in both conditions. Methodology/Principal Findings: The study is based on vessels of 15 explanted human renal allografts with AV and 10 carotid artery plaques obtained at surgery. Distribution and frequency of cytotoxic- and regulatory T cells, as identified by the expression of Granzyme B (GrB) and FOXP3 was established in NA and AV. Furthermore, we compared the distribution of these cells in AV with the perivascular, interstitial renal tissue using immunohistochemistry. The total number of T cells was much higher in AV than in NA lesions (711 6135 and 3768 CD3/mm2 respectively, p,0.005, mean, 6 SEM). Total numbers of FOXP3+ + 2 regulat