spatiotemporal air pollution exposure assessment for a canadian population-based lung cancer case-control study时空的空气污染暴露评估肺癌加拿大以人群为基础的病例对照研究.pdfVIP

Hystad et al. Environmental Health 2012, 11:22 /content/11/1/22 RESEARCH Open Access Spatiotemporal air pollution exposure assessment for a Canadian population-based lung cancer case-control study 1* 2 3 4 5 6 Perry Hystad , Paul A Demers , Kenneth C Johnson , Jeff Brook , Aaron van Donkelaar , Lok Lamsal , Randall Martin7 and Michael Brauer8 Abstract Background: Few epidemiological studies of air pollution have used residential histories to develop long-term retrospective exposure estimates for multiple ambient air pollutants and vehicle and industrial emissions. We present such an exposure assessment for a Canadian population-based lung cancer case-control study of 8353 individuals using self-reported residential histories from 1975 to 1994. We also examine the implications of disregarding and/or improperly accounting for residential mobility in long-term exposure assessments. Methods: National spatial surfaces of ambient air pollution were compiled from recent satellite-based estimates (for PM and NO ) and a chemical transport model (for O ). The surfaces were adjusted with historical annual air 2.5 2 3 pollution monitoring data, using either spatiotemporal interpolation or linear regression. Model evaluation was conducted using an independent ten percent subset of monitoring data per year. Proximity to major roads, incorporating a temporal weighting factor based on Canadian mobile-source emission estimates, was used to estimate exposure to vehicle emissions. A comprehensive inventory of geocoded industries was used to estimate proximity to major and minor industrial emissions. Results: Calibration of the national