原创力文档specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery特定的核被膜跨膜蛋白可以促进染色体的位置和核外围.pdfVIP
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specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery特定的核被膜跨膜蛋白可以促进染色体的位置和核外围
Specific nuclear envelope transmembrane
proteins can promote the location of
chromosomes to and from the nuclear periphery
Zuleger et al.
Zuleger et al. Genome Biology 2013, 14:R14
/2013/14/2/R14 (15 February 2013)
Zuleger et al. Genome Biology 2013, 14:R14
/2013/14/2/R14
RESEARCH Open Access
Specific nuclear envelope transmembrane
proteins can promote the location of
chromosomes to and from the nuclear periphery
1 2 1 1 1 1
Nikolaj Zuleger , Shelagh Boyle , David A Kelly , Jose I de las Heras , Vassiliki Lazou , Nadia Korfali ,
1 3,4 3,4 5 2
Dzmitry G Batrakou , K Natalie Randles , Glenn E Morris , David J Harrison , Wendy A Bickmore and
Eric C Schirmer1*
Abstract
Background: Different cell types have distinctive patterns of chromosome positioning in the nucleus. Although
ectopic affinity-tethering of specific loci can be used to relocate chromosomes to the nuclear periphery,
endogenous nuclear envelope proteins that control such a mechanism in mammalian cells have yet to be widely
identified.
Results: To search for such proteins, 23 nuclear envelope transmembrane proteins were screened for their ability
to promote peripheral localization of human chromosomes in HT1080 fibroblasts. Five of these proteins had strong
effects on chromosome 5, but individual proteins affected different subsets of chromosomes. The repositioning
effects were reversible and the proteins with effects all exhibited highly tissue-restricted patterns of expression.
Depletion
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