spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via tlr9-dependent crosstalk with myeloid dendritic cells球形乳酸菌激活血浆树突细胞免疫调节功能通过tlr9-dependent相声髓系树突状细胞.pdfVIP

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2017-09-12 发布于上海
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spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via tlr9-dependent crosstalk with myeloid dendritic cells球形乳酸菌激活血浆树突细胞免疫调节功能通过tlr9-dependent相声髓系树突状细胞.pdf

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spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via tlr9-dependent crosstalk with myeloid dendritic cells球形乳酸菌激活血浆树突细胞免疫调节功能通过tlr9-dependent相声髓系树突状细胞

Spherical Lactic Acid Bacteria Activate Plasmacytoid Dendritic Cells Immunomodulatory Function via TLR9- Dependent Crosstalk with Myeloid Dendritic Cells 1,2 1 1 1 3 1 Kenta Jounai , Kumiko Ikado , Tetsu Sugimura , Yasuhisa Ano , Jonathan Braun , Daisuke Fujiwara * 1 Central Laboratories for Frontier Technology, Kirin Holdings Co., Ltd., Kanazawa, Yokohama, Japan, 2 Technical Development Center, Koiwai Dairy Foods Co., Ltd., Sayama, Japan, 3 Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America Abstract Plasmacytoid dendritic cells (pDC) are a specialized sensor of viral and bacterial nucleic acids and a major producer of IFN-a that promotes host defense by priming both innate and acquired immune responses. Although synthetic Toll-like receptor (TLR) ligands, pathogenic bacteria and viruses activate pDC, there is limited investigation of non-pathogenic microbiota that are in wide industrial dietary use, such as lactic acid bacteria (LAB). In this study, we screened for LAB strains, which induce pDC activation and IFN-a production using murine bone marrow (BM)-derived Flt-3L induced dendritic cell culture. Microbial strains with such activity on pDC were absent in a diversity of bacillary strains, but were observed in certain spherical species (Lactococcus, Leuconostoc, Streptococcus and Pediococcus), which was correlated with their capacity for uptake by pDC. Detailed study of Lactococcus lactis subsp. lactis JCM5805 and JCM20101 revealed that the major type I and type III interferons were induced (IFN-a, - b, and