standardizing clinical trials workflow representation in uml for international site comparison在uml规范临床试验工作流程表示国际网站的比较.pdfVIP

Standardizing Clinical Trials Workflow Representation in UML for International Site Comparison 1 2 1 Elias Cesar Araujo de Carvalho , Madhav Kishore Jayanti , Adelia Portero Batilana , Andreia M. O. 1 1 1,3 4 9 5,6 Kozan , Maria J. Rodrigues , Jatin Shah , Marco R. Loures , Sunita Patil , Philip Payne , Ricardo Pietrobon3,7,8* 1 Research on Research Group, Department of Surgery, Duke University, Durham, North Carolina, United States of America, 2 Biomedical Informatics Program, The Ohio State University College of Medicine, Columbus, Ohio, United States of America, 3 Duke-NUS Graduate Medical School, Singapore, Singapore, 4 Rheumatology, ´ ´ Department of Medicine, State University of Maringa, Maringa, Brazil, 5 Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States of America, 6 Biomedical Informatics Program, The Ohio State University Center for Clinical and Translational Science, Columbus, Ohio, United States of America, 7 Department of Surgery, Duke University Health System, Durham, North Carolina, United States of America, 8 Research on Research Group, Duke University, Durham, United States of America, 9 Kalpavriksha Healthcare and Research, Thane, India Abstract Background: With the globalization of clinical trials, a growing emphasis has been placed on the standardization of the workflow in order to ensure the reproducibility and reliability of the overall trial. Despite the importance of workflow evaluation, to our knowledge no previous studies have attempted to adapt existin