原创力文档statin therapy in critical illness an international survey of intensive care physicians’ opinions, attitudes and practice他汀类药物治疗严重疾病的一项国际调查重症监护医生的意见、态度和实践.pdfVIP
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statin therapy in critical illness an international survey of intensive care physicians’ opinions, attitudes and practice他汀类药物治疗严重疾病的一项国际调查重症监护医生的意见、态度和实践
Shankar-Hari et al. BMC Clinical Pharmacology 2012, 12:13
/1472-6904/12/13
RESEARCH ARTICLE Open Access
Statin therapy in critical illness: an international
survey of intensive care physicians’ opinions,
attitudes and practice
1,2,3* 4,5 1,3 6,7 8
Manu Shankar-Hari , Peter S Kruger , Stefania Di Gangi , Damon C Scales , Gavin D Perkins ,
Danny F McAuley9 and Marius Terblanche1,2,3
Abstract
Background: Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and
possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ
failure. We conducted an international survey of intensive care physicians in Australia, New Zealand (ANZ) and
United Kingdom (UK). The aims of the survey were to assess the current prescribing practice patterns, attitudes
towards prescribing statin therapy in critically ill patients and opinions on the need for an interventional trial of
statin therapy in critically ill patients.
Methods: Survey questions were developed through an iterative process. An expert group reviewed the resulting
26 items for face and content validity and clarity. The questions were further refined following pilot testing by ICU
physicians from Australia, Canada and the UK. We used the online Smart SurveyTM software to administer the
survey.
Results: Of 239 respondents (62 from ANZ and 177 from UK) 58% worked in teaching hospitals; most (78.2%)
practised in ‘closed’ units with a mixed medical and surgical case mix (71.0%). The most frequently prescribed
statins were simvastatin (77.6%) in the UK and atorvastatin (66.1%) in ANZ. The main reasons cited to explain the
choice of statin were preadm
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