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statin use and ocular inflammatory disease risk他汀类药物使用和眼部炎症性疾病的风险
Yunker et al. Journal of Opthalmic Inflammation and Infection 2013, 3:8
/content/3/1/8
ORIGINAL RESEARCH Open Access
Statin use and ocular inflammatory disease risk
Jacob J Yunker1,2, Gerald McGwin Jr1,3,4 and Russell W Read1,5*
Abstract
Background: This study aims to evaluate the effect of oral statin medication use on the subsequent development
of ocular inflammatory disease (OID). A retrospective nested case–control study was carried out on patient records
from the Birmingham Veterans Affairs Medical Center. All male patients with a new diagnosis of OID over a 5-year
period were included. Ten control subjects (without OID) were age-matched to each OID case. Prescription files of
all subjects were queried for statin use. Information on selected comorbid medical conditions was also obtained.
Conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for risk of
OID development in the context of statin use, controlling for comorbid conditions.
Results: Ninety-two incident cases of OID were identified. A trend toward a reduction in the risk of new OID
development was found in patients that used statins compared to those that did not (OR 0.50, 95% CI 0.20 to 1.23,
p = 0.13). The longer the duration of statin use, the greater is the effect.
Conclusions: Use of oral statins may be associated with a reduced risk for the development of OID. This reduced
risk increases with increasing duration of use. Larger clinical studies would be required to definitively establish the
effectiveness of statins in lowering the incidence of OID.
Keywords: Uveitis, Statins, Epidemiology, Veteran
Background of suppression of inflammation with corticosteroids or
Uveitis refers to inflammation of the uveal
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