原创力文档statins inhibit angiotensin iismad pathway and related vascular fibrosis, by a tgf-β-independent process他汀类药物抑制血管紧张素iismad通路和相关血管纤维化tgf-β-independent过程.pdfVIP
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statins inhibit angiotensin iismad pathway and related vascular fibrosis, by a tgf-β-independent process他汀类药物抑制血管紧张素iismad通路和相关血管纤维化tgf-β-independent过程
Statins Inhibit Angiotensin II/Smad Pathway and Related
Vascular Fibrosis, by a TGF-b-Independent Process
´ ´ 1 ´ 1 1 1
Raul Rodrigues Dıez , Raquel Rodrigues-Dıez , Carolina Lavoz , Sandra Rayego-Mateos , Esther
1 ´ 1 2 3 ´ 4 1
Civantos , Juan Rodrıguez-Vita , Sergio Mezzano , Alberto Ortiz , Jesus Egido , Marta Ruiz-Ortega *
´
1 Cellular Biology in Renal Diseases Laboratory, Universidad Autonoma de Madrid, Madrid, Spain, 2 Division of Nephrology, School of Medicine, Universidad Austral,
´ ´ ´ ´ ´ ´ ´
Valdivia, Chile, 3 Dialysis Unit, Fundacion Jimenez Dıaz, Madrid, Spain, 4 Renal Research Laboratory, Fundacion Jimenez Dıaz, Universidad Autonoma de Madrid, Madrid,
Spain
Abstract
We have recently described that in an experimental model of atherosclerosis and in vascular smooth muscle cells (VSMCs)
statins increased the activation of the Smad pathway by transforming growth factor-b (TGF-b), leading to an increase in
TGF- b-dependent matrix accumulation and plaque stabilization. Angiotensin II (AngII) activates the Smad pathway and
contributes to vascular fibrosis, although the in vivo contribution of TGF-b has not been completely elucidated. Our aim was
to further investigate
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