原创力文档stereotactic body radiation therapy (sbrt) for unresectable pancreatic carcinoma立体定向放射治疗(sbrt)不可切除的胰癌.pdfVIP
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stereotactic body radiation therapy (sbrt) for unresectable pancreatic carcinoma立体定向放射治疗(sbrt)不可切除的胰癌
Cancers 2010, 2, 1565-1575; doi:10.3390/cancers2031565
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Review
Stereotactic Body Radiation Therapy (SBRT) for Unresectable
Pancreatic Carcinoma
Michael C. Stauder and Robert C. Miller *
Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA;
E-Mail: stauder.michael@
* Author to whom correspondence should be addressed; E-Mail: miller.robert@.
Received: 28 July 2010; in revised form: 5 August 2010 / Accepted: 6 August 2010 /
Published: 9 August 2010
Abstract: Survival in patients with unresectable pancreatic carcinoma is poor. Studies by
Mayo Clinic and the Gastrointestinal Tumor Study Group (GITSG) have established
combined modality treatment with chemotherapy and radiation as the standard of care. Use
of gemcitabine-based chemotherapy alone has also been shown to provide a benefit, but
5-year overall survival still remains less than 5%. Conventional radiotherapy is
traditionally delivered over a six week period and high toxicity is seen with the
concomitant use of chemotherapy. In contrast, SBRT can be delivered in 3–5 days and,
when used as a component of combined modality therapy with gemcitabine, disruption to
the timely delivery of chemotherapy is minimal. Early single-institution reports of SBRT
for unresectable pancreatic carcinoma demonstrate excellent local control with acceptable
toxicity. Use of SBRT in unresectable pancreatic carcinoma warr
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