sterilization of exopolysaccharides produced by deep-sea bacteria impact on their stability and degradation灭菌的深海细菌产生的胞外对其稳定性的影响和退化.pdfVIP

sterilization of exopolysaccharides produced by deep-sea bacteria impact on their stability and degradation灭菌的深海细菌产生的胞外对其稳定性的影响和退化.pdf

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sterilization of exopolysaccharides produced by deep-sea bacteria impact on their stability and degradation灭菌的深海细菌产生的胞外对其稳定性的影响和退化

Mar. Drugs 2011, 9, 224-241; doi:10.3390/md9020224 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Sterilization of Exopolysaccharides Produced by Deep-Sea Bacteria: Impact on Their Stability and Degradation Emilie Rederstorff 1,2, Ahmed Fatimi 2, Corinne Sinquin 1, Jacqueline Ratiskol 1, Christophe Merceron 2, Claire Vinatier 2, Pierre Weiss 2 and Sylvia Colliec-Jouault 1,* 1 Laboratory of Biotechnology and Marine Molecules, French Research Institute for Exploitation of the Sea (IFREMER), Rue de l’Ile d’Yeu, BP 21105, 44311 Nantes Cedex 03, France; E-Mails: Emilie.Rederstorff@ifremer.fr (E.R.); Corinne.Sinquin@ifremer.fr (C.S.); Jacqueline.Ratiskol@ifremer.fr (J.R.) 2 INSERM UMRS 791, Laboratory of Osteo-Articular and Dental Tissue Engineering, School of Dental Surgery, University of Nantes, 1 Place Alexis Ricordeau, 44042 Nantes Cedex 1, France; E-Mails: ahmed.fatimi@univ-nantes.fr (A.F.); christophe.merceron@univ-nantes.fr (C.M.); claire.vinatier@sante.univ-nantes.fr (C.V.); pweiss@sante.univ-nantes.fr (P.W.) * Author to whom correspondence should be addressed; E-Mail: Sylvia.Colliec.Jouault@ifremer.fr; Tel.: +33-2-4037-4093; Fax: +33-2-4037-4071. Received: 23 December 2010; in revised form: 21 January 2011 / Accepted: 7 February 2011 / Published: 10 February 2011 Abstract: Polysaccharides are highly heat-sensitive macromolecules, so high temperature treatments are greatly destructive and cause considerable damage, such as a great decrease in both viscosity and molecular weight of the polymer. The tec

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