straightforward inference of ancestry and admixture proportions through ancestry-informative insertion deletion multiplexing简单推理的祖先和掺合料的比例通过ancestry-informative插入删除多路复用.pdfVIP

Straightforward Inference of Ancestry and Admixture Proportions through Ancestry-Informative Insertion Deletion Multiplexing 1,2 2 ´ 1,3,4 2 5 Rui Pereira , Christopher Phillips , Nadia Pinto , Carla Santos , Sidney Emanuel Batista dos Santos , ´ 1,3 ´ 2,6 ˜ 1 Antonio Amorim , Angel Carracedo , Leonor Gusmao * 1 IPATIMUP – Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal, 2 Institute of Forensic Sciences Luis Concheiro, University of Santiago de Compostela, Santiago de Compostela, Spain, 3 Faculty of Sciences, University of Porto, Porto, Portugal, 4 Mathematics Research Centre, University of Porto, ´ ´ ´ ´ ´ Porto, Portugal, 5 Laboratorio de Genetica Humana e Medica, Universidade Federal do Para, Belem, Brazil, 6 Genomics Medicine Group, CIBERER, University of Santiago de Compostela, Santiago de Compostela, Spain Abstract Ancestry-informative markers (AIMs) show high allele frequency divergence between different ancestral or geographically distant populations. These genetic markers are especially useful in inferring the likely ancestral origin of an individual or estimating the apportionment of ancestry components in admixed individuals or populations. The study of AIMs is of great interest in clinical genetics research, particularly to detect and correct for population substructure effects in case-control association studies, but also in population and forensic genetics studies. This work presents a set of 46 ancestry-informative insertion deletion polymorphisms selected to efficiently measure popula