strategies to optimize analgesia and sedation策略优化镇痛和镇静.pdfVIP

Available online /content/12/S3/S6 Review Strategies to optimize analgesia and sedation William D Schweickert1 and John P Kress2 1Division of Pulmonary, Allergy and Critical Care, University of Pennsylvania Medical Center, Spruce Street, Philadelphia, Pennsylvania 19104, USA 2Section of Pulmonary and Critical Care, University of Chicago Hospitals, Maryland Avenue, Chicago, Illinois 60637, USA Corresponding author: John P Kress, jkress@ Published: 14 May 2008 Critical Care 2008, 12(Suppl 3):S6 (doi:10.1186/cc6151) This article is online at /content/12/S3/S6 © 2008 BioMed Central Ltd Abstract tions, but a need for sedatives and analgesics to promote tolerance to the intensive care unit (ICU) environment is Achieving adequate but not excessive sedation in critically ill, mechanically ventilated patients is a complex process. Analgesics typically the rule. and sedatives employed in this context are extremely potent, and drug requirements and metabolism are unpredictable. Clinicians Sedation needs vary widely in mechanically ventilated patients. must have heightened awareness of the potential for enduring ICU patients frequently exhibit unpredictable pharmacology effects and are encouraged to employ strategies that maximize with accumulation of drug in tissue stores, resulting in a benefit while minimizing risk. Successful sedation protocols have t