原创力文档streptococcus pneumoniae clonal complex 199 genetic diversity and tissue-specific virulence肺炎链球菌克隆复杂199遗传多样性和组织毒性.pdfVIP
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streptococcus pneumoniae clonal complex 199 genetic diversity and tissue-specific virulence肺炎链球菌克隆复杂199遗传多样性和组织毒性
Streptococcus pneumoniae Clonal Complex 199: Genetic
Diversity and Tissue-Specific Virulence
1,2 3 4 1 5
Jonathan C. Thomas , Marisol Figueira , Kristopher P. Fennie , Alison S. Laufer , Yong Kong ,
6 3 1
Michael E. Pichichero , Stephen I. Pelton , Melinda M. Pettigrew *
1 Division of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America,
2 Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, 3 Boston University School of Medicine and Public
Health, Boston Medical Center, Boston, Massachusetts, United States of America, 4 Yale University School of Nursing, New Haven, Connecticut, United States of America,
5 Department of Molecular Biophysics and Biochemistry, W. M. Keck Foundation Biotechnology Resource Laboratory, New Haven, Connecticut, United States of America,
6 Rochester General Hospital Research Institute, Rochester, New York, United States of America
Abstract
Streptococcus pneumoniae is an important cause of otitis media and invasive disease. Since introduction of the heptavalent
pneumococcal conjugate vaccine, there has been an increase in replacement disease due to serotype 19A clonal complex
(CC)199 isolates. The goals of this study were to 1) describe genetic diversity among nineteen CC199 isolates from carriage,
middle ear, blood, and cerebrospinal fluid, 2) compare CC199 19A (n = 3) and 15B/C (n = 2) isolates in the chinchilla model
for pneumococcal disease, and 3) identify accessory genes associated with tissue-specific disease among a larger collection
of S. pneumoniae isolates
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