原创力文档streptozotocin-induced cytotoxicity, oxidative stress and mitochondrial dysfunction in human hepatoma hepg2 cells体外细胞毒性,氧化应激和线粒体功能障碍在人类肝癌hepg2细胞.pdfVIP
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streptozotocin-induced cytotoxicity, oxidative stress and mitochondrial dysfunction in human hepatoma hepg2 cells体外细胞毒性,氧化应激和线粒体功能障碍在人类肝癌hepg2细胞
Int. J. Mol. Sci. 2012, 13, 5751-5767; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Streptozotocin-Induced Cytotoxicity, Oxidative Stress and
Mitochondrial Dysfunction in Human Hepatoma HepG2 Cells
Haider Raza * and Annie John
Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, POBox
17666, Al Ain, United Arab Emirates; E-Mail: anniej@uaeu.ac.ae
* Author to whom correspondence should be addressed; E-Mail: h.raza@uaeu.ac.ae;
Tel.: +971-3-7137506; Fax: +971-3-7672033.
Received: 7 March 2012; in revised form: 12 April 2012 / Accepted: 26 April 2012 /
Published: 11 May 2012
Abstract: Streptozotocin (STZ) is an antibiotic often used in the treatment of different
types of cancers. It is also highly cytotoxic to the pancreatic beta-cells and therefore is
commonly used to induce experimental type 1 diabetes in rodents. Resistance towards
STZ-induced cytotoxicity in cancer cells has also been reported. Our previous studies have
reported organ-specific toxicity and metabolic alterations in STZ-induced diabetic rats.
STZ induces oxidative stress and metabolic complications. The precise molecular
mechanism of STZ-induced toxicity in different tissues and carcinomas is, however,
unclear. We have, therefo
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