stress and childhood asthma risk overlapping evidence from animal studies and epidemiologic research压力和儿童哮喘风险重叠的证据来自动物实验和流行病学研究.pdfVIP

ORIGINAL ARTICLE Stress and Childhood Asthma Risk: Overlapping Evidence from Animal Studies and Epidemiologic Research Rosalind J. Wright, MD, MPH Rapidly expanding evidence increasingly strengthens the evidence linking psychological factors to asthma and allergy expression. Parallel studies in animals and humans demonstrating the influence of prenatal maternal stress and early caregiving experiences on the disrupted regulation of defensive biological systems [eg, sympathetic and adrenomedullary (SAM) system and the hypothalamic- pituitary-adrenocortical (HPA) axis] provide strong proof of concept for this line of research. The consequent altered neuroimmune responses may influence the expression of immune-mediated disorders such as asthma as well as enhance an individual’s susceptibility to other environmental factors that may also contribute to asthma risk. Key words: asthma, childhood, interactions, prenatal, stress Introduction prenatal exposures, may negatively influence neuroendo- crine and immune developmental processes relevant to Efforts to understand the role of psychological stress in asthma risk. Although studies of mechanisms by which asthma expression and atopy are currently undergoing perinatal stress may increase the risk of childhood asthma rapid expansion in the context of our increased under- 9,10 are only beginning to emerge, proof of concept is standi