原创力文档stress hormones receptors in the amygdala mediate the effects of stress on the consolidation, but not the retrieval, of a non aversive spatial task应激激素受体在杏仁核调解在固结压力的影响,但不是检索,一个非厌恶空间任务.pdfVIP
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stress hormones receptors in the amygdala mediate the effects of stress on the consolidation, but not the retrieval, of a non aversive spatial task应激激素受体在杏仁核调解在固结压力的影响,但不是检索,一个非厌恶空间任务
Stress Hormones Receptors in the Amygdala Mediate the
Effects of Stress on the Consolidation, but Not the
Retrieval, of a Non Aversive Spatial Task
Amir Segev, Assaf Ramot, Irit Akirav*
Department of Psychology, University of Haifa, Haifa, Israel
Abstract
This study examined the effects of the arousal level of the rat and exposure to a behavioral stressor on acquisition,
consolidation and retrieval of a non-aversive hippocampal-dependent learning paradigm, the object location task. Learning
was tested under two arousal conditions: no previous habituation to the experimental context (high novelty stress/arousal
level) or extensive prior habituation (reduced novelty stress/arousal level). Results indicated that in the habituated rats,
exposure to an out-of-context stressor (i.e, elevated platform stress) impaired consolidation and retrieval, but not
acquisition, of the task. Non-habituated animals under both stressed and control conditions did not show retention of the
task. In habituated rats, RU-486 (10 ng/side), a glucocorticoid receptor (GR) antagonist, or propranolol (0.75 mg/side), a beta-
adrenergic antagonist, injected into the basolateral amygdala (BLA), prevented the impairing effects of the stressor on
consolidation, but not on retrieval. The CB1/CB2 receptor agonist WIN55,212-2 (WIN, 5 mg/side) microinjected into the BLA
did not prevent the effects of stress on either consolidation or retrieval. Taken together the results suggest that: (i) GR and
b-adrenergic receptors in the BLA mediate the impairing effects of stress on the consolidation, but not the retrieval, of a
neutral, non-aversive hippocampal-dependent task, (ii) the impairing effects of stress on hippocampal consolidation and
retrieval are mediated by different neural mechanisms (i.e., different neurotransmitters or different
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