subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions亚热带草花粉过敏原对亚热带地区过敏性呼吸道疾病很重要.pdfVIP

Davies et al. Clinical and Translational Allergy 2012, 2:4 /content/2/1/4 RESEARCH Open Access Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions 1* 1 1,2 1,2 1,2 Janet Mary Davies , Hongzhuo Li , Melissa Green , Michelle Towers and John Warrick Upham Abstract Background: Grass pollen allergens are a major cause of allergic respiratory disease but traditionally prescribing practice for grass pollen allergen-specific immunotherapy has favoured pollen extracts of temperate grasses. Here we aim to compare allergy to subtropical and temperate grass pollens in patients with allergic rhinitis from a subtropical region of Australia. Methods: Sensitization to pollen extracts of the subtropical Bahia grass (Paspalum notatum), Johnson grass (Sorghum halepense) and Bermuda grass (Cynodon dactylon) as well as the temperate Ryegrass (Lolium perenne) were measured by skin prick in 233 subjects from Brisbane. Grass pollen-specific IgE reactivity was tested by ELISA and cross-inhibition ELISA. Results: Patients with grass pollen allergy from a subtropical region showed higher skin prick diameters with subtropical Bahia grass and Bermuda grass pollens than with Johnson grass and Ryegrass pollens. IgE reactivity was higher with pollen of Bahia grass than Bermuda grass, Johnson grass and Ryegrass. Patients showed asymmetric cross-inhibition of IgE reactivity with subtropical grass pollens that was not blocked by temperate grass pollen allergens indicating the presence of species-specific IgE binding sites of subtropical grass pollen allergens that are not represented in temperate grass pollens. Conclusions: Subtropical grass pollen