supramolecular bioorganic chemistry nucleic acids recognition and synthetic vectors for gene transfer超分子有机化学核酸识别和合成基因转移载体.pdfVIP

Molecules 1999, 4, 180-203 molecules ISSN 1420-3049 MDPI Lecture Supramolecular Bioorganic Chemistry: Nucleic Acids Recognition and Synthetic Vectors for Gene Transfer* Jean-Pierre Vigneron Laboratoire de Chimie des Interactions Moléculaires (UPR 285), Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France Tel.: 33 1 44 27 13 74, Fax: +33 1 44 27 1356, E-mail: vigneron@cdf.in2p3.fr * The first MDPI lecture (/mdpilecture1.htm), Basel, Switzerland, 11 June 1999. Received: 7 June 1999 / Accepted: 9 June 1999 / Published: 2 July 1999 Abstract: Our works on nucleic acids recognition and synthetic vectors for gene transfer have been reviewed. Keywords: supramolecular bioorganic chemistry, nucleic acids recognition, gene transfer. 1. Introduction The results presented in this paper deal with two domains of bioorganic supramoleclar chemistry. Indeed, bioorganic chemistry is not only a source of inspiration but also a huge domain of applications for supramolecular chemistry. The first topic - nucleic acid recognition - illustrates the recognition and the transformation of a substrate by a receptor. The second one - design of synthetic vectors for gene transfer - concerns the transport of a substrate, a process which in this case involves very complex molecular assemblies. Thus, the two broad areas of supramolecular chemistry are illustrated: that of supramolecules and that of polymolecular assemblies. © 1999 by the authors. Reproduction of this article, by any means, is permitted for noncommercial purposes. Molecules 1999, 4