surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia表面活性剂缺乏蛋白质d小鼠与摄食过量有关,改变脂肪沉积,胰岛素抵抗,增加基底内毒素.pdfVIP

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2017-09-12 发布于上海
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surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia表面活性剂缺乏蛋白质d小鼠与摄食过量有关,改变脂肪沉积,胰岛素抵抗,增加基底内毒素.pdf

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surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia表面活性剂缺乏蛋白质d小鼠与摄食过量有关,改变脂肪沉积,胰岛素抵抗,增加基底内毒素

Surfactant Protein D Deficiency in Mice Is Associated with Hyperphagia, Altered Fat Deposition, Insulin Resistance, and Increased Basal Endotoxemia 1. 2. 1 1 Jacob V. Stidsen , Reza Khorooshi , Martin K. U. Rahbek , Katrine L. Kirketerp-Møller , 1 1 1 3 4 5 Pernille B. L. Hansen , Peter Bie , Karin Kejling , Susanne Mandrup , Samuel Hawgood , Ole Nielsen , 6 2 1 1 Claus H. Nielsen , Trevor Owens , Uffe Holmskov , Grith L. Sørensen * 1 Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark, 2 Department of Neurobiology Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark, 3 Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark, 4 School of Medicine, University of California San Francisco, San Francisco, United States of America, 5 Department of Pathology, Odense University Hospital, Odense, Denmark, 6 Institute for Inflammation Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Abstract Pulmonary surfactant protein D (SP-D) is a host defence lectin of the innate immune system that enhances clearance of pathogens and modulates inflammatory responses. Recently it has been found that systemic SP-D is associated with metabolic disturbances and that SP-D deficient mice are mildly obese. However, the mechanism behind SP-D’s role in energy metabolism is not known. Here we report t