swinholide j, a potent cytotoxin from the marine sponge theonella swinhoeiswinholide j,一个强有力的细胞毒素的海洋海绵theonella swinhoei.pdfVIP

Mar. Drugs 2011, 9, 1133-1141; doi:10.3390/md9061133 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei 1 1 1 2 Simona De Marino , Carmen Festa , Maria Valeria D’Auria , Thierry Cresteil , Cecile Debitus 3 and Angela Zampella 1,* 1 Department of Chemistry of Natural Compounds, University of Naples, “FedericoII”, via D. Montesano 49, 80131 Napoli, Italy; E-Mails: sidemari@unina.it (S.D.M.); carmen.festa@unina.it (C.F.); madauria@unina.it (M.V.D.) 2 Natural Substances Institute, la Terrasse Street, 91198 Gif sur Yvette Cedex, France; E-Mail: cresteil@rs-gif.fr 3 Polynesian Research Center on Island Biodiversity, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, French Polynesia, France; E-Mail: cecile.debitus@ird.fr * Author to whom correspondence should be addressed; E-Mail: azampell@unina.it; Tel.: +39-081-678525; Fax: +39-081-678552. Received: 23 May 2011; in revised form: 9 June 2011 / Accepted: 15 June 2011 / Published: 22 June 2011 Abstract: In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. Th