原创力文档synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues合成和antiplasmodial桦木酸和乌索酸类似物的活性.pdfVIP
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synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues合成和antiplasmodial桦木酸和乌索酸类似物的活性
Molecules 2012, 17, 12003-12014; doi:10.3390/molecules171012003
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Synthesis and Antiplasmodial Activity of Betulinic Acid and
Ursolic Acid Analogues
1 1 2 2
Adrine M. Innocente , Gloria N. S. Silva , Laura Nogueira Cruz , Miriam S. Moraes ,
Myna Nakabashi 2, Pascal Sonnet 3, Grace Gosmann 1, Célia R. S. Garcia 2 and
Simone C. B. Gnoatto 1,*
1 Laboratório de Fitoquímica e Síntese Orgânica, Faculdade de Farmácia, Programa de Pós-Graduação
em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul. Av. Ipiranga, 2752,
Porto Alegre 90610-000, RS, Brazil; E-Mails: a_innocente@.br (A.M.I.);
glorianarjara@.br (G.N.S.S.); grace.gosmann@ufrgs.br (G.G.)
2 Laboratório de Biologia Celular e Molecular de Plasmodium, Departamento de Fisiologia,
Instituto de Biociências, Universidade de São Paulo, USP. Rua do Matão, travessa 14, 321,
São Paulo 05508-900, SP, Brazil; E-Mails: laurancruz@ (L.N.C.);
miradun@.br (M.S.M.); mnakab@ib.usp.br (M.N.); cgarcia@usp.br (C.R.S.G.)
3 Laboratoire des Glucides, FRE CNRS 3517, UFR de Pharmacie Université de Picardie Jules Verne1,
Rue des Louvels, 80037 Amiens cedex 1, France
* Author to whom correspondence should be addressed; E-Mail: simone.gnoatto@ufrgs.br;
Tel.: +55-51-3308-5451; Fax: +55-51-3308-5313.
Received: 17 September 2012; in revised form: 24 September 2012 / Accepted: 7 October 2012 /
Published: 12 October 2012
Abstract:
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