原创力文档synthesis and in vitro antibacterial activity of 7-(3-amino-6,7-dihydro-2-methyl-2h-pyrazolo[4,3-c] pyridin-5(4h)-yl)fluoroquinolone derivatives7 -合成和体外抗菌活性(3-amino-6,7-dihydro-2-methyl-2h-pyrazolo[4、3 c]pyridin-5(4 h)- yl)氟喹诺酮类衍生品.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
synthesis and in vitro antibacterial activity of 7-(3-amino-6,7-dihydro-2-methyl-2h-pyrazolo[4,3-c] pyridin-5(4h)-yl)fluoroquinolone derivatives7 -合成和体外抗菌活性(3-amino-6,7-dihydro-2-methyl-2h-pyrazolo[4、3 c]pyridin-5(4 h)- yl)氟喹诺酮类衍生品
Molecules 2011, 16, 2626-2635; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Synthesis and In Vitro Antibacterial Activity of
7-(3-Amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]
Pyridin-5(4H)-yl)fluoroquinolone Derivatives
Xin Guo 1,2, Ming Liang Liu 1, Hui Yuan Guo 1, Yu Cheng Wang 1 and Ju Xian Wang 1,*
1 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union
Medical College, Beijing 100050, China
2 College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;
E-Mail:guoxincq@
* Author to whom correspondence should be addressed; E-Mail: wyc9999@;
Tel.: +86-10 Fax: +86-10
Received: 31 December 2010; in revised form: 16 March 2011 / Accepted: 18 March 2011 /
Published: 22 March 2011
Abstract: A series of novel 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-
5(4H)-yl)fluoroquinolone derivatives were designed, synthesized and characterized by
1H-NMR, MS and HRMS. These fluoroquinolones were evaluated for their in vitro
antibacterial activity against representative Gram-positive and Gram-negative strains.
Results reveal that most of the target compounds exhibit good growth inhibitory potency
against methicillin-resistant Staphylococcus epidermidis (MRSE) (MIC: 0.25–4 μg/mL)
and Streptococcus pneumoniae (MIC: 0.25–1 μg/mL). In addition, compound 8f is 8–128
fold more potent than the reference drugs gemifloxacin (GM), moxifloxacin (MX),
c
您可能关注的文档
- supplementation with xylanase and β-xylosidase to reduce xylo-oligomer and xylan inhibition of enzymatic hydrolysis of cellulose and pretreated corn stover补充与木聚糖酶和β-xylosidase减少xylo-oligomer和木聚糖酶水解的抑制纤维素和玉米秸秆预处理.pdf
- supply chain management and sustainability procrastinating integration in mainstream research供应链管理和可持续性拖延集成在主流的研究.pdf
- supply of neuraminidase inhibitors related to reduced influenza a (h1n1) mortality during the 2009–2010 h1n1 pandemic an ecological study供应相关的神经氨酸酶抑制剂降低甲型流感(h1n1)死亡率在2009 - 2010年甲型h1n1流感大流行的生态研究.pdf
- super-resolution reconstruction of remote sensing images using multifractal analysis使用多重分形分析遥感图像的超分辨率重建.pdf
- support for single major genes influencing fat androstenone level and development of bulbo-urethral glands in young boars支持单一影响脂肪主要基因bulbo-urethral腺体的雄烯酮水平和发展年轻的野猪.pdf
- supported by science what canadian naturopaths advertise to the public支持通过科学加拿大理疗家向公众宣传.pdf
- support of unrelated stem cell donor searches by donor center-initiated hla typing of potentially matching donors支持不相关的干细胞捐赠者捐赠center-initiated hla输入搜索的潜在匹配的捐献者.pdf
- support for a rare pattern of temperature-dependent sex determination in archaic reptiles evidence from two species of tuatara (sphenodon)支持一种罕见的模式与温度有关的证据在古老的爬行动物性别决定的两种大蜥蜴(冈).pdf
- supported phospholipid bilayer interaction with components found in typical room-temperature ionic liquids – a qcm-d and afm study支持磷脂双分子层交互组件发现在典型的室温离子液体u2014u2014qcm-d和afm研究.pdf
- support loss and q factor enhancement for a rocking mass microgyroscope支持损失和q因子增强大规模microgyroscope摇摆.pdf
- synthesis and in vitro antioxidant activity evaluation of 3-carboxycoumarin derivatives and qsar study of their dpph？ radical scavenging activity合成和体外抗氧化活性评价的定量构效关系研究3-carboxycoumarin衍生品和dpph 自由基清除活性.pdf
- synthesis and in vitro cytotoxic activity of compounds with pro-apoptotic potential合成和体外细胞毒性化合物与pro-apoptotic潜在的活性.pdf
- synthesis and in vitro cytotoxic evaluation of aminoquinones structurally related to marine isoquinolinequinones合成和体外细胞毒性评价海洋isoquinolinequinones aminoquinones结构有关.pdf
- synthesis and in vitro evaluation of new benzothiazole derivatives as schistosomicidal agents合成和体外评价新的苯并噻唑衍生物schistosomicidal代理.pdf
- synthesis and in vitro protein tyrosine kinase inhibitory activity of furan-2-yl(phenyl)methanone derivatives合成和体外蛋白质酪氨酸激酶抑制活性furan-2-yl(苯)methanone衍生品.pdf
- synthesis and insecticidal activities of new ester-derivatives of celangulin-v新酯衍生物的合成及杀虫活动celangulin-v.pdf
- synthesis and liquid crystalline properties of new diols containing azomethine groups合成和液体结晶性能的新二醇含有偶氮甲碱组.pdf
- synthesis and microbiological evaluation of new 2- and 2,3-diphenoxysubstituted naphthalene-1,4-diones with 5-oxopyrrolidine moieties合成和微生物评价新2 - 2,3-diphenoxysubstituted naphthalene-1,4-diones 5-oxopyrrolidine根.pdf
- synthesis and insecticidal activity of an oxabicyclolactone and novel pyrethroids合成和oxabicyclolactone和新颖的拟除虫菊酯的杀虫活性.pdf
- synthesis and modifications of phosphinic dipeptide analogues次膦二肽类似物的合成和修改.pdf
文档评论（0）