synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives合成和药理活性diterpenylnaphthoquinone衍生品.pdfVIP

Molecules 2011, 16, 8614-8628; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives 1 2 3 Mariano Walter Pertino , Cristina Theoduloz , Jose Antonio Palenzuela , 3 4 2 2 Maria del Mar Afonso , Erdem Yesilada , Francisco Monsalve , Paulo González , Daniel Droguett 2 and Guillermo Schmeda-Hirschmann 1,* 1 Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile 2 Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile 3 Instituto Universitario de Bio-Orgánica Antonio Gonzalez G., Universidad de La Laguna, Tenerife 38206, Spain 4 Faculty of Pharmacy, Yeditepe University, Istanbul 34755, Turkey * Author to whom correspondence should be addressed; E-Mail: schmeda@utalca.cl; Tel.: +56-71-200288; Fax: + 56-71-201573. Received: 13 September 2011; in revised form: 29 September 2011 / Accepted: 30 September 2011 / Published: 13 October 2011 Abstract: New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human c