synthesis of 3-n-sugar-substituted-2, 4(1h,3h)-quinazolinedionesas anti-angiogenesis agents合成3-n-sugar-substituted-2 4(1 h、3 h)-quinazolinedionesas抗血管生成代理.pdfVIP

下载本文档

1
0
约4.67万字
约 11页
2017-09-12 发布于上海
举报
版权申诉

synthesis of 3-n-sugar-substituted-2, 4(1h,3h)-quinazolinedionesas anti-angiogenesis agents合成3-n-sugar-substituted-2 4(1 h、3 h)-quinazolinedionesas抗血管生成代理.pdf

1、本文档共11页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

synthesis of 3-n-sugar-substituted-2, 4(1h,3h)-quinazolinedionesas anti-angiogenesis agents合成3-n-sugar-substituted-2 4(1 h、3 h)-quinazolinedionesas抗血管生成代理

Molecules 2009, 14, 2447-2457; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)- quinazolinediones as Anti-Angiogenesis Agents Conghai Huang, Xiangbao Meng, Jingrong Cui and Zhongjun Li * State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; E-mails: michaelhchh@ (C.H.), xbmeng@ (X.M.), jrcui@ (J.C.) * Author to whom correspondence should be addressed; E-mail: zjli@ (Z.L); Tel.:+86-10 Fax: 86-10 Received: 8 May 2009; in revised form: 27 May 2009 / Accepted: 2 June 2009 / Published: 8 July 2009 Abstract: A series of novel 3-N-sugar-substituted quinazolinediones were synthesized through the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3- (2-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity. Keywords: quinazolinediones; anti-angiogenesis; triphosgene 1. Introduction The development of an effective anti-cancer drug is still a major challenge in the field of drug discovery. It was reported that aminopeptidase N (APN) plays a crucial role in the degradation and invasion of extracellular matrices by fibrosarcoma cells [1]. It is also important in the proliferation and the activation of pathogenic T-cells [2]. Several APN inhib