synthesis of substituted 2-benzoylaminothiobenzamides and their ring closure to substituted 2-phenylquinazoline-4-thiones合成取代2-benzoylaminothiobenzamides及其环闭合2-phenylquinazoline-4-thiones代替.pdfVIP

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synthesis of substituted 2-benzoylaminothiobenzamides and their ring closure to substituted 2-phenylquinazoline-4-thiones合成取代2-benzoylaminothiobenzamides及其环闭合2-phenylquinazoline-4-thiones代替.pdf

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synthesis of substituted 2-benzoylaminothiobenzamides and their ring closure to substituted 2-phenylquinazoline-4-thiones合成取代2-benzoylaminothiobenzamides及其环闭合2-phenylquinazoline-4-thiones代替

Molecules 2001, 6, 323-337 molecules ISSN 1420-3049 Synthesis of Substituted 2-Benzoylaminothiobenzamides and Their Ring Closure to Substituted 2-Phenylquinazoline-4- thiones 1 2 3 1, Jiří Hanusek , Ludmila Hejtmánková , Lenka Kubicová and Miloš Sedlák * 1 Department of Organic Chemistry, University of Pardubice, Čs. legií 565, 532 10 Pardubice, Czech Republic, Tel. +420 40 603 7015, Fax +420 40 603 7068, e-mail: Jiri.Hanusek@upce.cz. 2 Research Institute of Pharmacy and Biochemistry, Kouřimská 17, 130 60 Prague 3, Czech Republic, Tel. +420 40 603 8011, Fax +420 40 603 7068, e-mail: jjirman@serverpce.czcom.cz 3 Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic, Tel. +420 49 5067339, Fax. +420 49 5210002, e-mail: kubicova@faf.cuni.cz * Author to whom correspondence should be addressed; e-mail: Milos.Sedlak@upce.cz. Received: 4 December 2000; in revised form 6 March 2001 / Accepted: 23 March 2001 / Published: 31 March 2001 Abstract: Acylation of 2-aminothiobenzamide or 2-methylaminothiobenzamide with substituted benzoyl chlorides has been used to synthesise the corresponding 2-benzoyl- aminothiobenzamides whose subsequent sodium methoxide-catalysed ring closure gives the corresponding quinazoline-4-thiones. These compounds were characterised by means of their 1H- and 13C-NMR spectra. The preferred tautom