原创力文档tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (tpop) study protocol for a randomized controlled trial立川项目预防创伤后应激障碍的多不饱和脂肪酸(tpop)为随机对照试验研究方案.pdfVIP
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Tachikawa project for prevention of
posttraumatic stress disorder with
polyunsaturated fatty acid (TPOP): study protocol
for a randomized controlled trial
Matsuoka et al.
Matsuoka et al. BMC Psychiatry 2013, 13:8
/1471-244X/13/8
Matsuoka et al. BMC Psychiatry 2013, 13:8
/1471-244X/13/8
STUDY PROTOCOL Open Access
Tachikawa project for prevention of
posttraumatic stress disorder with
polyunsaturated fatty acid (TPOP): study protocol
for a randomized controlled trial
Yutaka Matsuoka1,2,3,4*, Daisuke Nishi1,3,4, Naohiro Yonemoto2,4, Kei Hamazaki4,5, Kenta Matsumura3,4,
Hiroko Noguchi2,3,4, Kenji Hashimoto4,6 and Tomohito Hamazaki4,7
Abstract
Background: Preclinical and clinical studies suggest that supplementation with omega-3 fatty acids after trauma
might reduce subsequent posttraumatic stress disorder (PTSD). To date, we have shown in an open trial that PTSD
symptoms in critically injured patients can be reduced by taking omega-3 fatty acids, hypothesized to stimulate
hippocampal neurogenesis. The primary aim of the present randomized controlled trial is to examine the efficacy of
omega-3 fatty acid supplementation in the secondary prevention of PTSD following accidental injury, as compared
with placebo. This paper describes the rationale and protocol of this trial.
Methods/design: The Tachikawa Project for Prevention of Posttraumatic Stress Disorder with Polyunsaturated Fatty
Acid (TPOP) is a double-blinded, parallel group, randomized controlled trial to assess whether omega-3 fatty acid
supplementation can prevent PTSD symptoms among accident-injured patients consecutively admitted to an
intensive care unit. We plan to recruit accident-injured patients and follow them prospective
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