原创力文档targeting of a chlamydial protease impedes intracellular bacterial growth针对衣原体蛋白酶的阻碍细胞内细菌生长.pdfVIP
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targeting of a chlamydial protease impedes intracellular bacterial growth针对衣原体蛋白酶的阻碍细胞内细菌生长
Targeting of a Chlamydial Protease Impedes Intracellular
Bacterial Growth
1,2. 3,4. 1 2 1
Jan G. Christian , Julia Heymann , Stefan A. Paschen , Juliane Vier , Linda Schauenburg , Jan
5,6 3 ¨ 2 3,4
Rupp , Thomas F. Meyer , Georg Hacker *, Dagmar Heuer
¨ ¨
1 Institute for Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Munich, Germany, 2 Institute for Medical Microbiology and Hygiene,
University Hospital Freiburg, Freiburg, Germany, 3 Max Planck Institute for Infection Biology, Dept. Molecular Biology, Berlin, Germany, 4 Robert Koch-Institute, Junior
¨ ¨ ¨
Research Group 5, Berlin, Germany, 5 Institute of Medical Microbiology and Hygiene, University of Lubeck, Lubeck, Germany, 6 Medical Clinic III, UK-SH/Campus Lubeck,
¨
Lubeck, Germany
Abstract
Chlamydiae are obligate intracellular bacteria that propagate in a cytosolic vacuole. Recent work has shown that growth of
Chlamydia induces the fragmentation of the Golgi apparatus (GA) into ministacks, which facilitates the acquisition of host
lipids into the growing inclusion. GA fragmentation results from infection-associated cleavage of the integral GA protein,
golgin-84. Golgin-84-cleavage, GA fragmentation and growth of Chlamydia trachomatis can be blocked by the peptide
inhibitor WEHD-fmk. Here we identify the bacterial protease chlamydial protease-like ac
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