tasco? a product of ascophyllum nodosum enhances immune response of caenorhabditis elegans against pseudomonas aeruginosa infectiontasco ascophyllum结节性提高的产物秀丽隐杆线虫对铜绿假单胞菌感染的免疫反应.pdfVIP
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tasco? a product of ascophyllum nodosum enhances immune response of caenorhabditis elegans against pseudomonas aeruginosa infectiontasco ascophyllum结节性提高的产物秀丽隐杆线虫对铜绿假单胞菌感染的免疫反应
Mar. Drugs 2012, 10, 84-105; doi:10.3390/m
OPEN ACCESS
Marine Drugs
ISSN 1660-3397
/journal/marinedrugs
Article
Tasco® : A Product of Ascophyllum nodosum Enhances Immune
Response of Caenorhabditis elegans Against Pseudomonas
aeruginosa Infection
1 2 3 3
Saveetha Kandasamy , Wajahatullah Khan , Franklin Evans , Alan T. Critchley and
Balakrishnan Prithiviraj 1,*
1 Department of Environmental Sciences, Nova Scotia Agricultural College, P.O. Box 550,
Truro, NS, B2B 5E3, Canada; E-Mail: skandasamy@nsac.ca
2 Genome Research Chair Unit, Department of Biochemistry, College of Science,
King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia; E-Mail: wkhan@.sa
3 Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth, NS, B3B 1X8, Canada;
E-Mails: fevans@acadian.ca (F.E.); alan.critchley@acadian.ca (A.T.C.)
* Author to whom correspondence should be addressed; E-Mail: bprithiviraj@nsac.ca;
Tel.: +1-902-893-6643; Fax: +1-902-893-1404.
Received: 28 November 2011; in revised form: 27 December 2011 / Accepted: 5 January 2012 /
Published: 11 January 2012
Abstract: The effects of Tasco®, a product made from the brown seaweed (Ascophyllum
nodosum) were tested for the ability to protect Caenorhabditis elegans against
Pseudomonas aeruginosa infection. A water extract of Tasco® (TWE) reduced
P. aeruginosa inflicted mortality in the nematode. The TWE, at a concentratio
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