synthesis of 4h-3,1-benzoxazin-4-one 2-phenyl using cyanuric chloride as a cyclization agent合成4 h-3 1-benzoxazin-4-one 2-phenyl使用氰尿酰氯作为环化剂.pdfVIP

下载本文档

0
0
约 3页
2017-11-02 发布于上海
举报
版权申诉

synthesis of 4h-3,1-benzoxazin-4-one 2-phenyl using cyanuric chloride as a cyclization agent合成4 h-3 1-benzoxazin-4-one 2-phenyl使用氰尿酰氯作为环化剂.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

synthesis of 4h-3,1-benzoxazin-4-one 2-phenyl using cyanuric chloride as a cyclization agent合成4 h-3 1-benzoxazin-4-one 2-phenyl使用氰尿酰氯作为环化剂

Molbank 2004 Molbank 2005, M448 /molbank/ Synthesis of 4H-3,1-benzoxazin-4-one 2-phenyl Using Cyanuric Chloride as a Cyclization Agent Sohrab Abdollahi* and Mehdi Shariat Department of Chemistry Payamnoor University of Golpayegan, Golpayegan Iran email: sohrab202020@ Received: 15 July 2005 / Accepted: 24 October 2004 / Published: 12 December 2005 Keywords: The preparation of different derivatives of benzoxazinone can be considered important because they have different kinds of pharmaceutical, agricultural and industrial applications [14]. The synthesis of benzoxazinone derivative, 4H3,1benzoxazin4one 2(Nphthaloylmethyl), was reported previously by our team [5]. In this paper we have used the same method to synthesize 4H3,1benzoxazin4one 2phenyl 5. This synthesis occurs in two steps: In the first step, anthranilic acid 1 (4.11g) in 40 ml chloroform was mixed with 4.15 ml anhydrous triethylamine and 3.48 ml benzoyl chloride 2 in 10 ml chloroform. In the second step, the resulting benzamid 3 (2.41 g) mixed with 100 ml anhydrous toluene, 1.52 ml triethylamine and 1.84 g cyanuric chloride 4 is refluxed for one week. After purification, drying with magnesium sulfate, the resulting benzoxazinone 5 as a final product is recrystallized in 30% ether chloroform solution. Yield 67.8 % (63% overall) For the compound 3: 1 HNMR (CDCl ): δ= 7.109.13 (m, 9H, ArH; NH); 12.112.3 (broad singlet,COOH).