原创力文档t-cell phenotypes, apoptosis and inflammation in hiv+ patients on virologically effective cart with early atherosclerosishiv阳性患者的t细胞表型,细胞凋亡和炎症与早期动脉粥样硬化例病毒学有效的车.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
t-cellphenotypes,apoptosisandinflammationinhivpatientsonvirologicallyeffectivecartwithearlyatherosclerosishiv阳性患者的t细胞表型,细胞凋亡和炎症与早期动脉粥样硬化例病毒学有效的车
T-Cell Phenotypes, Apoptosis and Inflammation in HIV+
Patients on Virologically Effective cART with Early
Atherosclerosis
Esther Merlini1., Kety Luzi 1., Elisa Suardi 1, Alessandra Barassi2, Maddalena Cerrone 1, Javier
´ ´ 1, Francesca Bai 1, Gian Vico Melzi D’Eril2, Antonella D’Arminio Monforte 1,
Sanchez Martınez
Giulia Marchetti1*
1 Clinic of Infectious Diseases and Tropical Medicine, Department of Health Sciences, University of Milan, San Paolo Hospital, Milan, Italy, 2 Laboratory of Clinical Analyses,
Department of Health Sciences, University of Milan, San Paolo Hospital, Milan, Italy
Abstract
Objective: We investigated the potential relationship between T-cell phenotype, inflammation, endotoxemia, and
atherosclerosis evaluated by carotid intima-media thickness (IMT) in a cohort of HIV-positive patients undergoing long-term
virologically suppressive combination antiretroviral therapy (cART).
Design: We studied 163 patients receiving virologically suppressive cART.
Methods: We measured IMT (carotid ultrasound); CD4+/CD8+ T-cell activation (CD38, CD45R0), differentiation (CD127),
apoptosis (CD95), and senescence (CD28, CD57) (flow cytometry); plasma sCD14, IL-6, TNF- a, sVCAM-1, hs-CRP, anti-CMV
IgG (ELISA); LPS (LAL). The results were compared by Mann-Whitney, Kruskal-Wallis or Chi-square tests, and factors
associated with IMT were evaluated by multivariable logistic regression.
Results: Of 163 patients, 112 demonstrated normal IMT (nIMT), whereas 51 (31.3%) had pathological IMT (pIMT: $1 mm). Of
the patients with pIMT, 22 demonstrated an increased IMT (iIMT), and 29 were shown to have plaques. These patient groups
had comparable nadir and current CD4+, VLs and total length of time on cART. Despite similar proportions of CD38-
expres
您可能关注的文档
- synthesis of benzofuran derivatives via rearrangement and their inhibitory activity on acetylcholinesterase通过重排香豆酮衍生物的合成及其对乙酰胆碱酯酶的抑制活性.pdf
- synthesis of aryliron complexes [cpfe(co)2ar] by palladium-catalyzed reactions of [cpfe(co)2i] with arylzinc, -boron, or -indium reagentsaryliron复合物的合成(cpfe(co)2 ar]的钯催化的反应[cpfe(co)2我]arylzinc,硼或铟试剂.pdf
- synthesis of azanucleosides through regioselective ring-opening of epoxides catalyzed by sulphated zirconia under microwave and solvent-free conditions通过特定选择的合成azanucleosides催化环氧化合物开环的微波无溶剂条件下硫酸化氧化锆.pdf
- synthesis of bis (1-methyl-2-octynyl) etherbis(1-methyl-2-octynyl)醚的合成.pdf
- synthesis of biotin linkers with the activated triple bond donor [p-(n-propynoylamino)toluic acid] (pata) for efficient biotinylation of peptides and oligonucleotides合成生物素和激活链接器三键捐赠(p -(n-propynoylamino)甲苯酸)(pata)高效生物素酰化肽与寡核苷酸.pdf
- synthesis of bis-ureas from bis(o-nitrophenyl) carbonate合成的bis-ureas bis(o-nitrophenyl)碳酸盐.pdf
- synthesis of both ionic species of ammonium dithiocarbamate derived cholic acid moieties合成的胆酸衍生的二硫代氨基甲酸铵根离子物种.pdf
- synthesis of brushite particles in reverse microemulsions of the biosurfactant surfactin反向状的透钙磷石粒子的合成生物表面活性剂surfactin.pdf
- synthesis of bioactive microcapsules using a microfluidic device使用微流体装置合成生物活性微胶囊.pdf
- synthesis of certain pyrimidine derivatives as antimicrobial agents and anti-inflammatory agents某些嘧啶衍生物的合成抗菌药物和抗炎剂.pdf
- t-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying hla-drb1 shared epitope alleles类风湿性关节炎患者t细胞autoreactivity,citrullinated autoantigenic肽携带hla-drb1共享抗原决定基的等位基因.pdf
- t-cell-mediated control of autoimmunityt-cell-mediated控制自身免疫.pdf
- tcf7l2 polymorphisms and inflammatory markers before and after treatment with fenofibratetcf7l2多态性和炎症标记物与非诺贝特治疗前后.pdf
- t-cell responses to the dblα-tag, a short semi-conserved region of the plasmodium falciparum membrane erythrocyte protein 1dblα-tag t细胞反应,短semi-conserved地区恶性疟原虫膜红细胞蛋白质1.pdf
- t-cell immune responses against env from crf12_bf and subtype b hiv-1 show high clade-specificity that can be overridden by multiclade immunizationst细胞免疫反应对env crf12_bf和hiv - 1 b亚型可以覆盖显示高clade-specificity multiclade免疫接种.pdf
- t-cell mediated immune responses induced in ret transgenic mouse model of malignant melanomat细胞介导免疫反应诱导恶性黑色素瘤的ret转基因小鼠模型.pdf
- t-cell contact-dependent regulation of cc and cxc chemokine production in monocytes through differential involvement of nfκb implications for rheumatoid arthritist细胞contact-dependent监管cc和科学家在单核细胞趋化因子生产通过微分的参与nfκb对类风湿性关节炎的影响.pdf
- tcr affinity for self-ligands influences the development and function of encephalitogenic t cells细胞受体亲和力self-ligands encephalitogenic t细胞的发育和功能的影响.pdf
- tea polyphenols and their roles in cancer prevention and chemotherapy茶多酚和他们的角色在癌症预防和化疗.pdf
- tdp-43 identified from a genome wide rnai screen for sod1 regulatorstdp-43确定从基因组广泛rnai屏幕sod1监管机构.pdf
文档评论（0）