原创力文档t-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying hla-drb1 shared epitope alleles类风湿性关节炎患者t细胞autoreactivity,citrullinated autoantigenic肽携带hla-drb1共享抗原决定基的等位基因.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
t-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying hla-drb1 shared epitope alleles类风湿性关节炎患者t细胞autoreactivity,citrullinated autoantigenic肽携带hla-drb1共享抗原决定基的等位基因
Law et al. Arthritis Research Therapy 2012, 14:R118
/content/14/3/R118
RESEARCH ARTICLE Open Access
T-cell autoreactivity to citrullinated autoantigenic
peptides in rheumatoid arthritis patients carrying
HLA-DRB1 shared epitope alleles
1† 1† 1 1 1
Soi Cheng Law , Shayna Street , Chien-Hsiung Alan Yu , Christelle Capini , Sakoontalla Ramnoruth ,
1 1 1 2 1 2 1*
Hendrik J Nel , Eline van Gorp , Claire Hyde , Kim Lau , Helen Pahau , Anthony W Purcell and Ranjeny Thomas
Abstract
Introduction: Anti-citrullinated peptide antibodies are found in rheumatoid arthritis (RA) patients with HLA-DRb
chains encoding the shared epitope (SE) sequence. Citrullination increases self-antigen immunogenicity, through
increased binding affinity to SE-containing HLA-DR molecules. To characterise T-cell autoreactivity towards
citrullinated self-epitopes, we profiled responses of SE+ healthy controls and RA patients to citrullinated and
unmodified epitopes of four autoantigens.
Methods: We compared T-cell proliferative and cytokine responses to citrullinated and native type II collagen 1,237
to 1,249, vimentin 66 to 78, aggrecan 84 to 103 and fibrinogen 79 to 91 in six SE+ healthy controls and in 21 RA
patients with varying disease duration. Cytokine-producing cells were stained after incubation with peptide in the
presence of Brefeldin-A.
Results: Although proliferative responses were low, IL-6, IL-17 and TNF were secreted by CD4+ T cells of SE+ RA
patients and healthy controls, as well as IFNg and IL-10 secreted
您可能关注的文档
- synthesis of benzofuran derivatives via rearrangement and their inhibitory activity on acetylcholinesterase通过重排香豆酮衍生物的合成及其对乙酰胆碱酯酶的抑制活性.pdf
- synthesis of aryliron complexes [cpfe(co)2ar] by palladium-catalyzed reactions of [cpfe(co)2i] with arylzinc, -boron, or -indium reagentsaryliron复合物的合成(cpfe(co)2 ar]的钯催化的反应[cpfe(co)2我]arylzinc,硼或铟试剂.pdf
- synthesis of azanucleosides through regioselective ring-opening of epoxides catalyzed by sulphated zirconia under microwave and solvent-free conditions通过特定选择的合成azanucleosides催化环氧化合物开环的微波无溶剂条件下硫酸化氧化锆.pdf
- synthesis of bis (1-methyl-2-octynyl) etherbis(1-methyl-2-octynyl)醚的合成.pdf
- synthesis of biotin linkers with the activated triple bond donor [p-(n-propynoylamino)toluic acid] (pata) for efficient biotinylation of peptides and oligonucleotides合成生物素和激活链接器三键捐赠(p -(n-propynoylamino)甲苯酸)(pata)高效生物素酰化肽与寡核苷酸.pdf
- synthesis of bis-ureas from bis(o-nitrophenyl) carbonate合成的bis-ureas bis(o-nitrophenyl)碳酸盐.pdf
- synthesis of both ionic species of ammonium dithiocarbamate derived cholic acid moieties合成的胆酸衍生的二硫代氨基甲酸铵根离子物种.pdf
- synthesis of brushite particles in reverse microemulsions of the biosurfactant surfactin反向状的透钙磷石粒子的合成生物表面活性剂surfactin.pdf
- synthesis of bioactive microcapsules using a microfluidic device使用微流体装置合成生物活性微胶囊.pdf
- synthesis of certain pyrimidine derivatives as antimicrobial agents and anti-inflammatory agents某些嘧啶衍生物的合成抗菌药物和抗炎剂.pdf
- t-cell-mediated control of autoimmunityt-cell-mediated控制自身免疫.pdf
- tcf7l2 polymorphisms and inflammatory markers before and after treatment with fenofibratetcf7l2多态性和炎症标记物与非诺贝特治疗前后.pdf
- t-cell responses to the dblα-tag, a short semi-conserved region of the plasmodium falciparum membrane erythrocyte protein 1dblα-tag t细胞反应,短semi-conserved地区恶性疟原虫膜红细胞蛋白质1.pdf
- t-cell immune responses against env from crf12_bf and subtype b hiv-1 show high clade-specificity that can be overridden by multiclade immunizationst细胞免疫反应对env crf12_bf和hiv - 1 b亚型可以覆盖显示高clade-specificity multiclade免疫接种.pdf
- t-cell mediated immune responses induced in ret transgenic mouse model of malignant melanomat细胞介导免疫反应诱导恶性黑色素瘤的ret转基因小鼠模型.pdf
- t-cell contact-dependent regulation of cc and cxc chemokine production in monocytes through differential involvement of nfκb implications for rheumatoid arthritist细胞contact-dependent监管cc和科学家在单核细胞趋化因子生产通过微分的参与nfκb对类风湿性关节炎的影响.pdf
- tcr affinity for self-ligands influences the development and function of encephalitogenic t cells细胞受体亲和力self-ligands encephalitogenic t细胞的发育和功能的影响.pdf
- tea polyphenols and their roles in cancer prevention and chemotherapy茶多酚和他们的角色在癌症预防和化疗.pdf
- tdp-43 identified from a genome wide rnai screen for sod1 regulatorstdp-43确定从基因组广泛rnai屏幕sod1监管机构.pdf
- tcm database@taiwan the world's largest traditional chinese medicine database for drug screening in silico中医database@taiwan世界最大的中药数据库硅片的药物筛选.pdf
文档评论（0）