原创力文档templated formation of hydroxyapatite nanoparticles from self-assembled nanogels containing tricarboxylate groups模板化形成的羟基磷灰石纳米粒子自组装纳米凝胶含有tricarboxylate组.pdfVIP
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templated formation of hydroxyapatite nanoparticles from self-assembled nanogels containing tricarboxylate groups模板化形成的羟基磷灰石纳米粒子自组装纳米凝胶含有tricarboxylate组
Polymers 2012, 4, 1056-1064; doi:10.3390/polym4021056
OPEN ACCESS
polymers
ISSN 2073-4360
/journal/polymers
Article
Templated Formation of Hydroxyapatite Nanoparticles from
Self-Assembled Nanogels Containing Tricarboxylate Groups
Yoshihiro Sasaki 1,2, Setsuko Yamane 3, Kei Kurosu 1, Shin-Ichi Sawada 4, 5
and Kazunari Akiyoshi 1,4, 5, *
1 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10
Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan; E-Mails: @tmd.ac.jp (Y.S.);
k.kurosu.bio@tmd.ac.jp (K.K.)
2 PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012,
Japan
3 Department of Chemistry and Biochemistry, Numazu National College of Technology, 3600 Ooka,
Numazu 410-8501, Japan; E-Mail: syamane@numazu-ct.ac.jp
4 Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan;
E-Mail: sawada@bio.polym.kyoto-u.ac.jp
5 ERATO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012,
Japan
* Author to whom correspondence should be addressed; E-Mail: akiyoshi@bio.polym.kyoto-u.ac.jp;
Tel.: +81-75-383-2589; Fax: +81-75-383-2590.
Received: 27 February 2012; in revised form: 10 April 2012 / Accepted: 11 April 2012 /
Published: 20 April 2012
Abstract: Nanosized hydroxyapatite (HAp) materials have received much attention in the
context of their advanced biomedical applications, including tissue engineering and drug
delivery systems. Hybridization of nanosized HAp with organic molecules is a promising
approach to facilitate the preparation
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