原创力文档tenomodulin inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathytenomodulin抑制视网膜新生血管形成的小鼠模型oxygen-induced视网膜病变.pdfVIP
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tenomodulin inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathytenomodulin抑制视网膜新生血管形成的小鼠模型oxygen-induced视网膜病变
Int. J. Mol. Sci. 2012, 13, 15373-15386; doi:10.3390/ijms131115373
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Tenomodulin Inhibits Retinal Neovascularization in a Mouse
Model of Oxygen-Induced Retinopathy
Wei Wang 1,*, Zhongqiu Li 1, Tatsuhiko Sato 2 and Yusuke Oshima 2
1 Department of Ophthalmology, Beijing Chao-Yang Hospital, Capital Medical University,
Beijing 100020, China; E-Mail: lizhqiu@
2 Department of Ophthalmology and Visual Science, Osaka University Medical School, Yamadaoka,
Suita, Osaka 5650871, Japan; E-Mails: tatsusatou@ (T.S.);
oshima@ophthal.med.osaka-u.ac.jp (Y.O.)
* Author to whom correspondence should be addressed; E-Mail: wendy_wen81@;
Tel.: +86-10-8523-1343.
Received: 14 September 2012; in revised form: 9 October 2012/ Accepted: 14 November 2012 /
Published: 20 November 2012
Abstract: We aimed to determine the anti-angiogenic effect of tenomodulin (TeM) on
retinal neovascularization in an oxygen-induced retinopathy (OIR) mouse model. OIR was
induced in C57BL/6 mice by exposing seven-day-old mice to 75% oxygen for five days
followed by room air for five days. Control mice were exposed to room air from birth until
postnatal day 17. Mice received intravitreal injections of 1 μg of TeM in one eye and PBS in
the contralateral eye at P7 before being exposed to 75% oxygen. Eyes were collected at
postnatal day 17. Retinal blood vessel patterns were visualized
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