terpenes from marine-derived fungi萜烯从marine-derived真菌.pdfVIP

Mar. Drugs 2010, 8, 2340-2368; doi:10.3390/md8082340 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Review Terpenes from Marine-Derived Fungi Rainer Ebel Marine Biodiscovery Centre, University of Aberdeen, Meston Walk, Aberdeen, AB24 3UE, Scotland, UK; E-Mail: r.ebel@abdn.ac.uk; Tel.: +44-1224-27-2930; Fax: +44-1224-27-2921 Received: 6 July 2010; in revised form: 21 July 2010 / Accepted: 9 August 2010 / Published: 13 August 2010 Abstract: Terpenes from marine-derived fungi show a pronounced degree of structural diversity, and due to their interesting biological and pharmacological properties many of them have aroused interest from synthetic chemists and the pharmaceutical industry alike. The aim of this paper is to give an overview of the structural diversity of terpenes from marine-derived fungi, highlighting individual examples of chemical structures and placing them in a context of other terpenes of fungal origin. Wherever possible, information regarding the biological activity is presented. Keywords: marine-derived fungi; natural products chemistry; terpenes; biological activity 1. Introduction Marine-derived fungi continue to produce chemically diverse new natural products with interesting pharmacological properties [1–3]. In terms of the overall number of secondary metabolites, polyketides are clearly dominating the chemical literature, followed by prenylated polyketides (―meroterpenes‖), peptides and alkaloids. Terpenes, which are in the focus of this special issue of M