synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles a review of the literature from 2000–2012合成方法和药理作用的1、3,则对文献之回顾从2000 - 2012.pdfVIP

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synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles a review of the literature from 2000–2012合成方法和药理作用的1、3,则对文献之回顾从2000 - 2012.pdf

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synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles a review of the literature from 2000–2012合成方法和药理作用的1、3,则对文献之回顾从2000 - 2012

Molecules 2012, 17, 10192-10231; doi:10.3390/molecules170910192 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012 Cledualdo Soares de Oliveira 1, Bruno Freitas Lira 1, José Maria Barbosa-Filho 2, Jorge Gonçalo Fernandez Lorenzo 2 and Petrônio Filgueiras de Athayde-Filho 1,* 1 Department of Chemistry, Federal University of Paraíba, 58051-900 João Pessoa-PB, Brazil; E-Mails: aldoscarchi@.br (C.S.O.); brunofrlira@ (B.F.L.) 2 Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-900 João Pessoa-PB, Brazil; E-Mails: jbarbosa@ltf.ufpb.br (J.M.B.-F.); jgflorenzo@ (J.G.F.L.) * Author to whom correspondence should be addressed; E-Mail: athayde-filho@quimica.ufpb.br; Tel.: +55-83-3216-7937. Received: 23 July 2012; in revised form: 15 August 2012 / Accepted: 17 August 2012 / Published: 27 August 2012 Abstract: This review provides readers with an overview of the main synthetic methodologies for 1,3,4-oxadiazole derivatives, and of their broad spectrum of pharmacological activities as reported over the past twelve years. Keywords: 1,3,4-oxadiazole; synthesis methods; pharmacological activity; review 1. Introduction 1,3,4-Oxadiazole (1, Figure 1) is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five-membered ring. It is derived from furan by substitution of two methylene groups (=CH) with two pyr