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synorth exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomessynorth探索同线性的进化和远程监管在脊椎动物基因组的相互作用.pdf

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synorth exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomessynorth探索同线性的进化和远程监管在脊椎动物基因组的相互作用

Volume 10, Issue 8, Article R86et al.Dong2009 Open Access Software Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes Xianjun Dong*†, David Fredman*‡ and Boris Lenhard*† Addresses: *Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway. †Sars Centre for Marine Molecular Biology, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway. ‡Current address: Department for Molecular Evolution and Development, Centre for Organismal Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse, 1090 Wien, Austria. Correspondence: Boris Lenhard. Email: boris.lenhard@bccs.uib.no Published: 21 August 2009 Received: 29 March 2009 Revised: 22 June 2009 Genome Biology 2009, 10:R86 (doi:10.1186/gb-2009-10-8-r86) Accepted: 21 August 2009 The electronic version of this article is the complete one and can be found online at /2009/10/8/R86 © 2009 Dong et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited genomes./pGene regulatory block analysispSynorth is a web resource for exploring and categorizing the syntenic relationships in gene regulatory blocks across multiple Abstract Genomic regulatory blocks are chromosomal regions spanned by long clusters of highly conserved noncoding elements devoted to long-range regulation of development